RESEARCH AREA

Parkinson's Disease

Parkinson’s disease (PD) is a neurodegenerative disorder that affects predominantly dopamine-producing (“dopaminergic”) neurons in a specific area of the brain called substantia nigra.

Clinical Trials Currently Ongoing

BN42358 PADOVA (Hoffmann-La Roche)

Victorine Sikati Foko Recruitment is closed

BIA 28-6156-201 ACTIVATE (Bial R&D Investments)

Victorine Sikati Foko Recruitment is closed

Completed Clinical Trials

2023 BIAL (Phase II)
2021: BN42358 study (Phase IIb)
2014: iSTEP study (Phase III)
2011: CONFIDENT-PD study (Phase II)
2010: AFQ056A2217 study (Phase II)
2010: AFQ056A2208 study (Phase II)

Symptoms & Cause

Symptoms generally develop slowly over years. The progression of symptoms is often a bit different from one person to another due to the diversity of the disease. People with PD may experience:

Tremor, mainly at rest and described as pill-rolling tremor in hands. Other forms of tremor are possible

The cause remains largely unknown. Although there is no cure, treatment options vary and include medications and surgery. While Parkinson’s itself is not fatal, disease complications can be serious.

Diagnose & Treatment

There is no “one way” to diagnose Parkinson’s disease (PD). However, there are various symptoms and diagnostic tests used in combination. Making an accurate diagnosis of Parkinson’s — particularly in its early stages — is difficult.

There is no standard treatment for Parkinson’s disease (PD). Treatment for each person with Parkinson’s is based on his or her symptoms. Treatments can include medications, physical therapy, surgical options, medical marijuana, clinical trials, lifestyle modifications, like getting more rest and exercise.

There are many medications available to treat Parkinson’s symptoms, although none yet that reverse the effects of the disease. It is common for people with PD to take a variety of these medications — all at different doses and at different times of day — to manage symptoms.

Importance of clinical research

Scientists and doctors are working together to find a treatment or prevention technique. The clinical research will help to attract the attention of the federal and state government as well as the pharmaceutical industry to the growing need and urgency in addressing PD. This is an important first step to better understanding who develops PD and why. We participate in a number of clinical trials aiming to create advancements for the treatment of Multiple SclerosisStrokeParkinson’sAlzheimer’s and Glioblastoma Multiforme (GBM). Our participation allows us to offer many treatments long before they become available to a majority of specialists, giving patients an opportunity to choose from a wide range of care that, while experimental in nature, may possibly be more effective. Cutting edge treatments aren’t the only reason we conduct clinical trials, nor are they the only reason patients decide to participate. Our involvement gives us the opportunity to develop better protocols and, most importantly, to help advance the treatments themselves. When it comes to Neurological diseases, large strides have been made in recent years; results that would have been impossible without the participation of Doctors, Nurses and, most of all, patients.

Parkinson's Disease

Parkinson’s disease research has achieved tremendous strides in the past decades. Research has ranged from better understanding of the underlying disease mechanisms and how to improve symptomatic treatments to interventions that slow down or halt the disease progression.

CLINICAL TRIALS

CNO is involved in clinical trials looking at therapies whose objective is to slow or halt disease progression.

Studies Recruiting

Please enquire. As of writing CNO does not have a trial recruiting

Studies Ongoing

Padova OLE
Victorine Sikati Foko Recruitment is closed
 
BIA 28-6156-201/ Activate
Contact Victorine Sikati Foko Recruitment is closed

Studies Completed

Our Services Include:

About rTMS for Parkinson’s Disease:

Transcranial magnetic stimulation (rTMS) is a non-invasive technique that uses targeted magnetic pulses to modulate brain activity. Research studies (see published articles) suggest it may help alleviate symptoms such as:

While promising, rTMS remains an experimental treatment for Parkinson’s Disease and is not currently covered by public health insurance (RAMQ/OHIP).

Completed